Impermanence is the absolute rule of this world, so it must be recognized as a law in your life. Phenomena are created, and they are subject to dissolution.
If you seek meaning in your life, you must acknowledge the reason for your life: You are here in this world for a reason. Because your life is the creation of your mind, unless you realize the mind there will be no way to fulfill the meaning of life. Once you realize the paramount importance of the mind – the source that creates all phenomena – you can fully grasp the meaning of your life.